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Module 9.2 Host-pathogen interactions

Module objectives

Understanding of mechanisms used by various major pathogens to invade and hijack the cellular machinery.

Methodological and technical skills acquired

Methods for the study of interactions of cells with viruses, bacteria or parasites based on specific examples (in vitro cell culture infection models, imaging, protein-protein interactions, tools to inhibit the expression or function of specific proteins).

Program and content of the module

Theoretical courses : 20h

  • The cytoskeleton.
  • Parasitic invasion.
  • Bacteria adhesion.
  • Secretion systems and host-bacteria.
  • Bacteria entry into cells - interaction with the cytoskeleton.
  • Virus entry: trafficking from membrane to nucleus.
  • Viruses and autophagy.
  • Viruses and lipids.
  • Morphogenesis of enveloped viruses: Herpesvirus.
  • Virus-cytoskeleton interaction.
  • Morphogenesis of enveloped viruses : hepadna & flavivirus.
  • Viral cell-to-cell dissemination.
  • Interference and restriction of retroviruses.
  • Viruses and DNA damage.
  • Interactions of Mycobacteria with host cells.

Tutorials : 10h

  • Critical analysis of English written scientific publications in relation with programs of UE 9.1, 9.2, 9.4, 9.6, 9.7, 9.8 et 9.9.
  • Track A only (pair working): Fifteen minutes oral presentation of a scientific publication followed by 15 minutes of questions by the jury and other students of the track.