Share
Ecouter

Module 9.4 Induction and control of the immune response

Module objectives

Anti-infectious immune responses and vaccination strategies.

Methodological and technical skills acquired

The aim of this module is to bring theoretical and practical knowledge on antigen presenting cells and targeting strategies in vaccine development.

Program and content of the module

Theoretical courses : 22h

  • Workshop on dendritic cells sorting (Miltenyi).
  • Introductory course to flow cytometry (Miltenyi).
  • General presentation on dendritic cells.
  • Dendritic cells and antigen presentation.
  • Plasmacytoid dendritic cells.
  • Immunity of the newborn. Impact of the micro-environment on the nature and function of dendritic cells.
  • Granulocytes and macrophages as the first line of defense in avian diseases. Role of defensins and chemokines in the induction of the immune response in the context of vaccine development.
  • Interaction between domestic animals dendritic cells and viruses.
  • Macrophages, dendritic cells and leshmania seen from the parasite point of view.
  • Cholera toxin and mucosal dendritic cells.

Practical courses : 8h

  • Lymphocyte purification from murine spleens, staining and FACS analyses.
  • Critical analysis of English written scientific publications in relation with programs of UE 9.1, 9.2, 9.4, 9.6, 9.7, 9.8 et 9.9.