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Module 9.7a Molecular mechanisms of resistance (Infectious agents and chemoresistance)

Objectives

Theoretical knowledge of resistance mechanisms to anti-microbial therapies (specific and non-specific mechanisms of resistance, escape by mutation, dissemination).

Program : 20h theoretical courses and 10h tutorials

 
  • Main resistance mechanisms of HIV and HCV to anti-viral drugs.
  • Basis of genetic and phenotypic tests to assess the level of resistance to antiviral drugs (with a particular focus on HIV, CMV and HCV).
  • Main antibiotic resistance mechanisms (detection methods, emphasis on beta-lactamases and active efflux,…).
  • Genetic supports of antibiotic resistance (characterization, integrons, plasmids, integrative islands,…).
  • Horizontal transfer and persistence of antibiotic resistance (conjugation,…).
  • Specific resistance anthelmintics mechanisms (parasitic nematodes, levamisole, diagnostics, genetic and functional approaches).
  • Non-specific anthelmintic resistance mechanisms.