Module 9.8b Adjuvants and modulation of the immune response

• Presentation of the different adjuvant types on the market and in development.
• Criteria for the choice of an adjuvant.
• Micro and nano-technologies and vaccine strategy.

Different types of adjuvant, types of immune response to promote, criteria for selection of adjuvant.

• General knowledge on adjuvants, types of adjuvants (E. coli labile toxin mutants, oil- and surfactant-based adjuvants).
• Targeting innate immune receptors, ligands TLR (flagellin), TLRs and intestinal cells.
• Delivery adjuvants: liposomes, nano-particles, particle-based synthetic ligands.
• Routes of immunization: sublingual and transcutaneous routes.